Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation-Reference-Cited by-同舟云学术

Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation

Published:2020 Issue:6 Volume:18 Page:1140-1147
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Xu Lujuan¹²³⁴⁵,Raabe Marco¹²³⁴⁵^ORCID,Zegota Maksymilian M.¹²³⁴⁵,Nogueira João C. F.⁶⁷⁸⁹,Chudasama Vijay⁶⁷⁸⁹^ORCID,Kuan Seah Ling¹²³⁴⁵^ORCID,Weil Tanja¹²³⁴⁵^ORCID

Affiliation:

1. Max Planck Institute for Polymer Research

2. 55128 Mainz

3. Germany

4. Institute of Inorganic Chemistry I

5. University of Ulm

6. Department of Chemistry

7. University College London

8. London

9. UK

Abstract

Site-selective incorporation of a reactive tetrazine tag into therapeutically relevant peptides and proteins via disulfide rebridging allows fast preparation of stable bioconjugates “on-demand”.

Funder

Max-Planck-Gesellschaft

Deutsche Forschungsgemeinschaft

China Scholarship Council

H2020 Marie Skłodowska-Curie Actions

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02687H