Site-selective protein modification via disulfide rebridging for fast tetrazine/trans-cyclooctene bioconjugation
Author:
Affiliation:
1. Max Planck Institute for Polymer Research
2. 55128 Mainz
3. Germany
4. Institute of Inorganic Chemistry I
5. University of Ulm
6. Department of Chemistry
7. University College London
8. London
9. UK
Abstract
Site-selective incorporation of a reactive tetrazine tag into therapeutically relevant peptides and proteins via disulfide rebridging allows fast preparation of stable bioconjugates “on-demand”.
Funder
Max-Planck-Gesellschaft
Deutsche Forschungsgemeinschaft
China Scholarship Council
H2020 Marie Skłodowska-Curie Actions
Horizon 2020 Framework Programme
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/OB/C9OB02687H
Reference53 articles.
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