Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities-Reference-Cited by-同舟云学术

Functionalization of 68Ga-Radiolabeled Nanodiamonds with Octreotide Does Not Improve Tumor-Targeting Capabilities

Published:2024-04-17 Issue:4 Volume:17 Page:514
ISSN:1424-8247
Container-title:Pharmaceuticals
language:en
Short-container-title:Pharmaceuticals

Author:

Wanek Thomas¹²^ORCID,Raabe Marco³⁴⁵^ORCID,Alam Md Noor A³⁴,Filip Thomas²⁶,Stanek Johann¹²,Loebsch Mathilde²⁷,Laube Christian⁸^ORCID,Mairinger Severin²⁹^ORCID,Weil Tanja³⁴,Kuntner Claudia¹²¹⁰^ORCID

Affiliation:

1. Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, 1090 Vienna, Austria

2. Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria

3. Synthesis of Macromolecules, Max Planck Institute for Polymer Research, 55128 Mainz, Germany

4. Institute of Inorganic Chemistry I, Ulm University, 89081 Ulm, Germany

5. Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 115201, Taiwan

6. Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria

7. Core Facility Laboratory Animal Breeding and Husbandry (CFL), Medical University of Vienna, 1090 Vienna, Austria

8. Leibniz-Institute of Surface Engineering (IOM), 04318 Leipzig, Germany

9. Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

10. Medical Imaging Cluster (MIC), Medical University of Vienna, 1090 Vienna, Austria

Abstract

Nanodiamonds (NDs) are emerging as a novel nanoparticle class with growing interest in medical applications. The surface coating of NDs can be modified by attaching binding ligands or imaging probes, turning them into multi-modal targeting agents. In this investigation, we assessed the targeting efficacy of octreotide-functionalized 68Ga-radiolabelled NDs for cancer imaging and compared it with the tumor uptake using [68Ga]Ga-DOTA-TOC. In vivo studies in mice bearing AR42J tumors demonstrated the highest accumulation of the radiolabeled functionalized NDs in the liver and spleen, with relatively low tumor uptake compared to [68Ga]Ga-DOTA-TOC. Our findings suggest that, within the scope of this study, functionalization did not enhance the tumor-targeting capabilities of NDs.

Funder

European Union’s Horizon 2020 research and innovation program

Publisher

MDPI AG

Link

https://www.mdpi.com/1424-8247/17/4/514/pdf

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