Context contribution to the intermolecular recognition of human ACE2-derived peptides by SARS-CoV-2 spike protein: implications for improving the peptide affinity but not altering the peptide specificity by optimizing indirect readout-Reference-Cited by-同舟云学术

Context contribution to the intermolecular recognition of human ACE2-derived peptides by SARS-CoV-2 spike protein: implications for improving the peptide affinity but not altering the peptide specificity by optimizing indirect readout

Published:2021 Issue:1 Volume:17 Page:86-94
ISSN:2515-4184
Container-title:Molecular Omics
language:en
Short-container-title:Mol. Omics

Author:

Zhou Peng¹²³⁴⁵^ORCID,Wang Heyi¹²³⁴⁵,Chen Zheng¹²³⁴⁵,Liu Qian¹²³⁴⁵

Affiliation:

1. Center for Informational Biology

2. University of Electronic Science and Technology of China (UESTC) at Qingshuihe Campus

3. Chengdu 611731

4. China

5. School of Life Science and Technology

Abstract

Disrupting the intermolecular interaction of SARS-CoV-2 S protein with its cell surface receptor hACE2 is a therapeutic strategy against COVID-19. The protein context plays an essential role in hACE α1-helix recognition by viral S protein.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Genetics,Molecular Biology,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MO/D0MO00103A

Reference34 articles.

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2. SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat

3. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response