A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

Author:

Xia Shuai1ORCID,Yan Lei2ORCID,Xu Wei1ORCID,Agrawal Anurodh Shankar3,Algaissi Abdullah34,Tseng Chien-Te K.3,Wang Qian1,Du Lanying5,Tan Wenjie6,Wilson Ian A.27ORCID,Jiang Shibo15ORCID,Yang Bei2ORCID,Lu Lu1ORCID

Affiliation:

1. Shanghai Public Health Clinical Center and School of Basic Medical Sciences, and Key Laboratory of Medical Molecular Virology of MOE/MOH, Fudan University, Shanghai 200032, China.

2. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China.

3. Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

4. Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.

5. Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA.

6. MOH Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

7. Department of Integrative Structural and Computational Biology and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC206, La Jolla, CA 92037, USA.

Abstract

EK1 is a broad-spectrum human coronavirus fusion inhibitor for combating infection of current and emerging coronaviruses.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People’s Republic of China

the Shanghai Rising-Star Program

National Megaprojects of China for Major Infectious Diseases

The Sanming Project of Medicine in Shenzhen

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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