Design and synthesis of metabolic chemical reporters for the visualization and identification of glycoproteins

Author:

Pedowitz Nichole J.123,Pratt Matthew R.12345ORCID

Affiliation:

1. Department of Chemistry, University of Southern California

2. Los Angeles

3. USA

4. Department of Biological Sciences

5. University of Southern California

Abstract

This review details a brief history of the synthesis and characterization of metabolic chemical reporters used to study glycosylation before describing recent applications and finishing with considerations and limitations of reporter molecules.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Reference122 articles.

1. M. E. E. Ajit Varki , R. D.Cummings , J. D.Esko , H. H.Freeze , P.Stanley , C. R.Bertozzi and G. W.Hart , Essentials of Glycobiology , Cold Spring Harbor Laboratory Press , New York, NY , 2nd edn, 2009

2. Glycosylation in Cellular Mechanisms of Health and Disease

3. Chemical Approaches to Glycobiology

4. The Metabolism of l-Fucose

5. Biosynthesis of a nonphysiological sialic acid in different rat organs, using N-propanoyl-D-hexosamines as precursors.

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