A zinc/PyBisulidine catalyzed asymmetric Mannich reaction of N-tosyl imines with 3-acyloxy-2-oxindoles-Reference-Cited by-同舟云学术

A zinc/PyBisulidine catalyzed asymmetric Mannich reaction of N-tosyl imines with 3-acyloxy-2-oxindoles

Published:2021 Issue:34 Volume:19 Page:7460-7469
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yang Zinan¹,He Huakang¹,Tian Rui¹²,Wu Ruoran¹,Hu Sheng¹³,Wu Yue¹,Zhou Hui¹^ORCID

Affiliation:

1. Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China

2. Pharmaceutical Teaching Laboratory Center, Chongqing Medical University, Chongqing, China

3. Department of Hepatobiliary Surgery, Chongqing 4th Hospital, Chongqing, China

Abstract

Various quaternary substituted 3-acyloxy-2-oxindoles bearing vicinal amino alcohol motifs were obtained via a Zn–PyBisulidine catalyzed asymmetric Mannich reaction of 3-acyloxy-2-oxindoles.

Funder

Chongqing Municipal Education Commission

National Natural Science Foundation of China

Natural Science Foundation of Chongqing

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01328A

Reference41 articles.

1. 3-Substituted-3-hydroxy-2-oxindole, an Emerging New Scaffold for Drug Discovery with Potential Anti-Cancer and other Biological Activities

2. Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

3. Catalytic asymmetric synthesis of 3-hydroxyoxindole: a potentially bioactive molecule

4. Metal Catalysis versus Organocatalysis in the Catalytic Asymmetric Synthesis of 3-Hydroxyoxindole

5. Recent advances in the asymmetric catalytic synthesis of chiral 3-hydroxy and 3-aminooxindoles and derivatives: Medicinally relevant compounds

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