High diastereo- and enantioselective Michael addition of 3-acetoxy-2-oxindoles with nitroalkenes catalyzed by nickel/PyBisulidine-Reference-Cited by-同舟云学术

High diastereo- and enantioselective Michael addition of 3-acetoxy-2-oxindoles with nitroalkenes catalyzed by nickel/PyBisulidine

Published:2023 Issue:30 Volume:21 Page:6225-6229
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wu Ruoran¹,Chen Peng¹,Chai Yu¹,Zhou Junyu¹,Ou Jianhua¹,Min Yan¹,Wang Haoting¹,Liang Guojuan¹,Zhang Dong¹,Zhou Jing¹^ORCID,Zhou Hui¹^ORCID

Affiliation:

1. Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China

Abstract

A Ni/PyBisulidine catalyzed asymmetric Michael addition of 3-acyloxy-2-oxindoles to nitroalkenes is developed to construct quaternary substituted 3-acyloxy-2-oxindoles with excellent yields and stereoselectivities in low catalyst loading (1 mol%).

Funder

Natural Science Foundation of Chongqing

Chongqing Municipal Education Commission Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB01024D

Reference40 articles.

1. Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids

2. Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

3. Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

4. Antioxidant Properties of Sour Cherries (Prunus cerasus L.): Role of Colorless Phytochemicals from the Methanolic Extract of Ripe Fruits

5. 3-Substituted-3-hydroxy-2-oxindole, an Emerging New Scaffold for Drug Discovery with Potential Anti-Cancer and other Biological Activities

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