The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase-Reference-Cited by-同舟云学术

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase

Published:2017 Issue:4 Volume:8 Page:796-806
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Eastman Kyle J.¹²³⁴^ORCID,Parcella Kyle¹²³⁴,Yeung Kap-Sun¹²³⁴,Grant-Young Katharine A.¹²³⁴,Zhu Juliang¹²³⁴,Wang Tao¹²³⁴,Zhang Zhongxing¹²³⁴,Yin Zhiwei¹²³⁴,Beno Brett R.¹²³⁴,Sheriff Steven¹²³⁴,Kish Kevin¹²³⁴,Tredup Jeffrey¹²³⁴,Jardel Adam G.¹²³⁴,Halan Vivek¹²³⁴,Ghosh Kaushik¹²³⁴,Parker Dawn¹²³⁴,Mosure Kathy¹²³⁴,Fang Hua¹²³⁴,Wang Ying-Kai¹²³⁴,Lemm Julie¹²³⁴,Zhuo Xiaoliang¹²³⁴,Hanumegowda Umesh¹²³⁴,Rigat Karen¹²³⁴,Donoso Maria¹²³⁴,Tuttle Maria¹²³⁴,Zvyaga Tatyana¹²³⁴,Haarhoff Zuzana¹²³⁴,Meanwell Nicholas A.¹²³⁴,Soars Matthew G.¹²³⁴,Roberts Susan B.¹²³⁴,Kadow John F.¹²³⁴

Affiliation:

1. Bristol-Myers Squibb Pharmaceutical Research and Development

2. Department of Discovery Chemistry and Molecular Technologies

3. Wallingford

4. USA

Abstract

A series of novel 7-azabenzofurans exhibiting pan-genotype inhibition of HCV NS5B polymerase via binding to the primer grip site is presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

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