The Discovery of Asunaprevir (BMS-650032), An Orally Efficacious NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Author:

Scola Paul M.1,Sun Li-Qiang1,Wang Alan Xiangdong1,Chen Jie1,Sin Ny1,Venables Brian L.1,Sit Sing-Yuen1,Chen Yan1,Cocuzza Anthony1,Bilder Donna M.1,D’Andrea Stanley V.1,Zheng Barbara1,Hewawasam Piyasena1,Tu Yong1,Friborg Jacques2,Falk Paul2,Hernandez Dennis2,Levine Steven2,Chen Chaoqun2,Yu Fei2,Sheaffer Amy K.2,Zhai Guangzhi2,Barry Diana2,Knipe Jay O.3,Han Yong-Hae3,Schartman Richard3,Donoso Maria3,Mosure Kathy3,Sinz Michael W.3,Zvyaga Tatyana4,Good Andrew C.5,Rajamani Ramkumar5,Kish Kevin6,Tredup Jeffrey6,Klei Herbert E.6,Gao Qi7,Mueller Luciano8,Colonno Richard J.2,Grasela Dennis M.9,Adams Stephen P.3,Loy James3,Levesque Paul C.3,Sun Huabin3,Shi Hong3,Sun Lucy3,Warner William3,Li Danshi3,Zhu Jialong3,Meanwell Nicholas A.1,McPhee Fiona2

Affiliation:

1. Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut, 06492, United States

2. Department of Virology Discovery Biology, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut, 06492, United States

3. Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut, 06492, United States

4. Department of Lead Discovery and Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut, 06492, United States

5. Department of Computer-Assisted Drug Design, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut, 06492, United States

6. Department of Protein Science and Structure, Bristol-Myers Squibb Research and Development, PO Box 5400 Princeton, New Jersey, 08543, United States

7. Department of Pharmaceutical Development, Bristol-Myers Squibb Research and Development, 1 Squibb Drive, New Brunswick, New Jersey, 08903, United States

8. Department of Mechanistic Biochemistry, Bristol-Myers Squibb Research and Development, PO Box 5400 Princeton, New Jersey, 08543, United States

9. Department of Clinical Development Infectious Disease, Bristol-Myers Squibb Research and Development, PO Box 5400 Princeton, New Jersey, 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Cited by 96 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3