Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection-Reference-Cited by-同舟云学术

Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Published:2014-02-20 Issue:5 Volume:57 Page:1708-1729
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Scola Paul M.¹,Wang Alan Xiangdong¹,Good Andrew C.²,Sun Li-Qiang¹,Combrink Keith D.¹,Campbell Jeffrey A.¹,Chen Jie¹,Tu Yong¹,Sin Ny¹,Venables Brian L.¹,Sit Sing-Yuen¹,Chen Yan¹,Cocuzza Anthony¹,Bilder Donna M.¹,D’Andrea Stanley¹,Zheng Barbara¹,Hewawasam Piyasena¹,Ding Min¹,Thuring Jan¹,Li Jianqing³,Hernandez Dennis⁴,Yu Fei⁴,Falk Paul⁴,Zhai Guangzhi⁴,Sheaffer Amy K.⁴,Chen Chaoqun⁴,Lee Min S.⁴,Barry Diana⁴,Knipe Jay O.⁵,Li Wenying⁵,Han Yong-Hae⁵,Jenkins Susan⁵,Gesenberg Christoph⁵,Gao Qi⁶,Sinz Michael W.⁵,Santone Kenneth S.⁵,Zvyaga Tatyana⁷,Rajamani Ramkumar²,Klei Herbert E.²,Colonno Richard J.⁴,Grasela Dennis M.⁸,Hughes Eric⁸,Chien Caly⁸,Adams Stephen⁵,Levesque Paul C.⁵,Li Danshi⁵,Zhu Jialong⁵,Meanwell Nicholas A.¹,McPhee Fiona⁴

Affiliation:

1. Department of Discovery Chemistry, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

2. Department of Computer-Assisted Drug Design, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

3. Department of Discovery Chemical Synthesis, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

4. Department of Virology Discovery Biology, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

5. Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

6. Department of Pharmaceutical Development, Bristol-Myers Squibb Research and Development, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

7. Department of Lead Discovery and Optimization, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

8. Department of Early Clinical and Translational Research, Discovery Medicine—Virology, Bristol-Myers Squibb Research and Development, Hopewell, New Jersey 08543, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401840s

Reference84 articles.

1. Global epidemiology and burden of hepatitis C

2. Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalence

3. Epidemiology and natural history of HCV infection

4. Pathogenesis of hepatitis C—associated hepatocellular carcinoma

Cited by 57 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Hepatitis C: The Story of a Long Journey through First, Second, and Third Generation NS3/4A Peptidomimetic Inhibitors. What Did We Learn?;Journal of Medicinal Chemistry;2024-01-05

2. X-ray crystallographic study, molecular docking, molecular dynamics and DFT/ADMET analyses of carboxylsulfamides;Journal of Molecular Structure;2023-10

3. Successes in antiviral drug discovery: a tribute to Nick Meanwell;Medicinal Chemistry Research;2023-06-08

4. Applications of Bioisosteres in the Design of Biologically Active Compounds;Journal of Agricultural and Food Chemistry;2023-03-24

5. Useful Computational Chemistry Tools for Medicinal Chemistry;The Handbook of Medicinal Chemistry;2023-02-03