An efficient catalyst-free one-pot synthesis of primary amides from the aldehydes of the Baylis–Hillman reaction

Author:

Narendar Reddy Thatikonda12345ORCID,Raktani Bikshapathi12345,Perla Ramesh6274ORCID,Ravinder Mettu12345,Vaidya Jayathirtha Rao12345ORCID,Babu N. Jagadeesh8274

Affiliation:

1. Crop Protection Chemicals Division

2. CSIR-Indian Institute of Chemical Technology

3. Hyderabad 500007

4. India

5. AcSIR

6. Natural Products Chemistry Division

7. Hyderabad-500007

8. Centre for X-ray Crystallography

Abstract

Herein, a facile and efficient method for the preparation of allyl amides from the aldehydes of Baylis–Hillman adducts has been developed using a hydroxylamine/methanol system under a catalyst-free condition.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Reference103 articles.

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2. A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases

3. The Amide Linkage: Structural Significance in Chemistry, Biochemistry, and Materials Science, ed. A. Greenberg, C. M. Breneman and J. F. Liebman, Wiley, New York, 2000

4. I. Johansson , in Kirk-Othmer Encyclopedia of Chemical Technology, Wiley, New York, 2004, vol. 2, p. 442

5. D. Lipp , in Encyclopedia of Chemical Technology, ed. J. I. Kroschwitz, John Wiley & Sons, New York, 1991, vol. 1, p. 266

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