Affiliation:
1. School of Life Sciences and Biopharmaceutical Sciences Shenyang Pharmaceutical University Shenyang 110016 People's Republic of China
2. School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 People's Republic of China
Abstract
AbstractThe combination of the catalytic power of amorphous metal‐organic frameworks (aMOFs) and biocatalysis has greatly boosted the development of novel synthetic strategies due to its functional diversity and stereospecificity. 2‐Cyanoacrylamides are important building blocks for many biologically active molecules. Herein, we described a chemical‐biological relay catalytic method to access (E)‐2‐cyanoacrylamides based on the catalysis of amorphous porphyrin‐MOFs SPUZ‐1 and whole cells of Rhodococcus rhodochrous (nitrile hydratase). The approach was proved to be simple and efficient, and the highest conversion was up to 99%
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Catalysis
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