Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)-Reference-Cited by-同舟云学术

Ebselen as a potent covalent inhibitor of New Delhi metallo-β-lactamase (NDM-1)

Published:2015 Issue:46 Volume:51 Page:9543-9546
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Chiou Jiachi¹²³⁴⁵,Wan Shengbiao⁶⁷⁸⁹¹⁰,Chan Kin-Fai¹¹¹²³¹³¹⁴,So Pui-Kin¹¹¹²³¹³¹⁴,He Dandan¹²³⁴⁵,Chan Edward Wai-chi¹²³⁴⁵,Chan Tak-hang¹¹¹²³¹³¹⁴,Wong Kwok-yin¹¹¹²³¹³¹⁴,Tao Jiang⁶⁷⁸⁹¹⁰,Chen Sheng¹²³⁴⁵

Affiliation:

1. Shenzhen Key Laboratory for Food Biological Safety Control

2. Food Safety and Technology Research Centre

3. The Hong Kong Polytechnic University

4. Shenzhen Research Institute

5. Shenzhen

6. Key Laboratory of Marine Drugs

7. Chinese Ministry of Education

8. School of Medicine and Pharmacy

9. Ocean University of China

10. Qingdao

11. State Key Laboratory of Chirosciences

12. Department of Applied Biology and Chemical Technology

13. Kowloon

14. Hong Kong

Abstract

We identified a potent NDM-1 inhibitor that formed a S–Se bond with the Cys²²¹ residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC02594J

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