α-Methyl phenylglycines by asymmetric α-arylation of alanine and their effect on the conformational preference of helical Aib foldamers-Reference-Cited by-同舟云学术

α-Methyl phenylglycines by asymmetric α-arylation of alanine and their effect on the conformational preference of helical Aib foldamers

Published:2018 Issue:15 Volume:16 Page:2757-2761
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Costil Romain¹²³⁴,Fernández-Nieto Fernando¹⁵⁶⁴,Atkinson Rachel C.¹⁵⁶⁴,Clayden Jonathan¹²³⁴^ORCID

Affiliation:

1. School of Chemistry

2. University of Bristol

3. Bristol BS8 1TS

4. UK

5. University of Manchester

6. Manchester M13 9PL

Abstract

Asymmetric arylation of an alanine derivative provides (R)-α-methyl phenylglycine, which induces a right handed screw sense in an Aib oligomer.

Funder

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB00551F

Reference32 articles.

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2. Helical peptaibol mimics are better ionophores when racemic than when enantiopure

3. Length-Dependent Formation of Transmembrane Pores by 310-Helical α-Aminoisobutyric Acid Foldamers

4. Mechanism of Stabilization of Helix Secondary Structure by Constrained Cα-Tetrasubstituted α-Amino Acids

5. Role of Secondary Structure in the Asymmetric Acylation Reaction Catalyzed by Peptides Based on Chiral Cα-Tetrasubstituted α-Amino Acids

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