Metal-dependent allosteric activation and inhibition on the same molecular scaffold: the copper sensor CopY from Streptococcus pneumoniae
Author:
Affiliation:
1. Department of Chemistry
2. Indiana University
3. Bloomington
4. USA
5. Department of Molecular and Cellular Biochemistry
6. Department of Biology
7. University of Massachusetts
Abstract
The dynamics and marginal stability of CopY enable allosteric activation of DNA binding by Zn(ii) and inhibition by Cu(i).
Funder
National Institute of General Medical Sciences
Pew Charitable Trusts
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/SC/C7SC04396A
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