A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes-Reference-Cited by-同舟云学术

A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes

Published:2023-01-26 Issue:1 Volume:205 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Komazin Gloria¹,Rizk Amena A.¹,Armbruster Krista M.¹²,Bonnell Victoria A.¹,Llinás Manuel¹³⁴^ORCID,Meredith Timothy C.¹³^ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA

2. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

3. The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA

4. Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, USA

Abstract

Copper is a frontline antimicrobial used to limit bacterial growth in multiple settings. Here, we demonstrate how the response regulator CopR from a plasmid-borne two-component system in the opportunistic pathogen L. monocytogenes directly induces lipoprotein remodeling in tandem with copper resistance genes due to extracellular copper stress.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00390-22

Reference87 articles.

1. Lipoproteins in bacteria: structures and biosynthetic pathways

2. Biogenesis and Membrane Targeting of Lipoproteins

3. Lipoproteins in Gram-Positive Bacteria: Abundance, Function, Fitness

4. A phylum level analysis reveals lipoprotein biosynthesis to be a fundamental property of bacteria

5. Mode of action of lipoprotein modification enzymes—Novel antibacterial targets

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Revisiting old friends: updates on the role of two-component signaling systems in Listeria monocytogenes survival and pathogenesis;Infection and Immunity;2024-04-09

2. The Extracellular Electron Transport Pathway Reduces Copper for Sensing by the CopRS Two-Component System under Anaerobic Conditions in Listeria monocytogenes;Journal of Bacteriology;2023-01-26