How the biomimetic assembly of membrane receptors into multivalent domains is regulated by a small ligand-Reference-Cited by-同舟云学术

How the biomimetic assembly of membrane receptors into multivalent domains is regulated by a small ligand

Published:2021 Issue:22 Volume:12 Page:7800-7808
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Grochmal Anna¹²³⁴⁵,Woods Ben¹²³⁴⁵,Milanesi Lilia¹²³⁴⁵,Perez-Soto Manuel¹²³⁴⁵^ORCID,Tomas Salvador¹²³⁴⁵^ORCID

Affiliation:

1. Department of Biological Sciences

2. Institute of Structural and Molecular Biology

3. School of Science

4. Birkbeck University of London

5. London WC1E 7HX

Abstract

In lipid vesicles near their membrane phase-transition temperature, the presence of a small, weakly binding ligand tips the balance for the assembly of multivalent receptor domains. We recapitulate this behaviour using a global binding-clustering model.

Funder

Leverhulme Trust

University of London

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC01598B

Reference32 articles.

1. Single-molecule analysis of fluorescently labeled G-protein-coupled receptors reveals complexes with distinct dynamics and organization

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