Proteoglycan-Specific Molecular Switch for RPTPσ Clustering and Neuronal Extension

Author:

Coles Charlotte H.1,Shen Yingjie2,Tenney Alan P.23,Siebold Christian1,Sutton Geoffrey C.1,Lu Weixian1,Gallagher John T.45,Jones E. Yvonne1,Flanagan John G.2,Aricescu A. Radu1

Affiliation:

1. Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.

2. Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.

3. Motor Neuron Center, Columbia University, New York, NY 10032, USA.

4. School of Cancer and Imaging Sciences, Faculty of Medical and Health Sciences, University of Manchester, Paterson Institute for Cancer Research, Manchester M20 4BX, UK.

5. Iduron, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, UK.

Abstract

One receptor binds two different types of proteoglycan at the same site but with divergent outcomes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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