Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions-Reference-Cited by-同舟云学术

Efficient synthesis of α-alkyl-β-amino amides by transaminase-mediated dynamic kinetic resolutions

Published:2019 Issue:15 Volume:9 Page:4083-4090
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Mourelle-Insua Ángela¹²³⁴⁵,Méndez-Sánchez Daniel¹²³⁴,Galman James L.⁵⁶⁷⁸⁹^ORCID,Slabu Iustina⁵⁶⁷⁸⁹,Turner Nicholas J.⁵⁶⁷⁸⁹^ORCID,Gotor-Fernández Vicente¹²³⁴^ORCID,Lavandera Iván¹²³⁴^ORCID

Affiliation:

1. Organic and Inorganic Chemistry Department

2. University of Oviedo

3. 33006 Oviedo

4. Spain

5. School of Chemistry

6. Manchester Institute of Biotechnology

7. University of Manchester

8. Manchester

9. UK

Abstract

A transaminase-catalyzed dynamic kinetic resolution is described for the stereoselective synthesis of a series of α-alkyl-β-amino amides.

Funder

Secretaría de Estado de Investigación, Desarrollo e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CY/C9CY01004A

Reference80 articles.

1. (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

2. Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors

3. Discovery of Potent and Selective Dipeptidyl Peptidase IV Inhibitors Derived from β-Aminoamides Bearing Subsituted Triazolopiperazines

4. Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes

5. Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

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