(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes-Reference-Cited by-同舟云学术

(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Published:2004-12-13 Issue:1 Volume:48 Page:141-151
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kim Dooseop¹,Wang Liping¹,Beconi Maria¹,Eiermann George J.¹,Fisher Michael H.¹,He Huaibing¹,Hickey Gerard J.¹,Kowalchick Jennifer E.¹,Leiting Barbara¹,Lyons Kathryn¹,Marsilio Frank¹,McCann Margaret E.¹,Patel Reshma A.¹,Petrov Aleksandr¹,Scapin Giovanna¹,Patel Sangita B.¹,Roy Ranabir Sinha¹,Wu Joseph K.¹,Wyvratt Matthew J.¹,Zhang Bei B.¹,Zhu Lan¹,Thornberry Nancy A.¹,Weber Ann E.¹

Affiliation:

1. Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0493156

Reference47 articles.

1. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

2. Truncated GLP-1 (proglucagon 78?107-amide) inhibits gastric and pancreatic functions in man

3. Genistein potentiates wild-type and delta F508-CFTR channel activity

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