Biocompatible nanocarriers for passive transdermal delivery of insulin based on self-adjusting N-alkylamidated carboxymethyl cellulose polysaccharides

Author:

Cohen Yael12,Cohen Guy34ORCID,Tworowski Dmitry5,Eretz-Kdosha Noy3,Silberstein Eldad6,Fallik Elazar1,Poverenov Elena1ORCID

Affiliation:

1. Agro-Nanotechnology and Advanced Materials Center, Institute of Postharvest and Food Sciences, Agricultural Research Organization, The Volcani Institute, Rishon LeZion 7505101, Israel

2. The Robert H Smith, Faculty of Agriculture, Food and Environment, Institute of Biochemistry, Food and Nutrition, The Hebrew University of Jerusalem, Rehovot 76100, Israel

3. The Skin Research Institute, Dead Sea & Arava Science Center, Masada 86910, Israel

4. Eilat Campus, Ben-Gurion University of the Negev, Eilat 8855630, Israel

5. Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel

6. Department of Plastic Surgery, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Abstract

In this work, we present biocompatible nanocarriers based on modified polysaccharides capable of transporting insulin macromolecules through human skin without any auxiliary techniques.

Funder

Ministry of Science and Technology, Israel

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Materials Science,General Chemistry,Atomic and Molecular Physics, and Optics,Bioengineering

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