Identification of novel functional mini-receptors by combinatorial screening of split-WW domains-Reference-Cited by-同舟云学术

Identification of novel functional mini-receptors by combinatorial screening of split-WW domains

Published:2022 Issue:31 Volume:13 Page:9079-9090
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Neitz Hermann¹^ORCID,Paul Niels Benjamin²^ORCID,Häge Florian R.³⁴^ORCID,Lindner Christina³⁴^ORCID,Graebner Roman³⁴^ORCID,Kovermann Michael⁵^ORCID,Thomas Franziska³⁴^ORCID

Affiliation:

1. Institute of Organic Chemistry, University of Würzburg, Am Hubland, Würzburg 97074, Germany

2. Institute of Organic and Biomolecular Chemistry, University of Göttingen, Tammannstr. 2, Göttingen 37077, Germany

3. Institute of Organic Chemistry, Heidelberg University, Im Neuenheimer Feld 270, Heidelberg 69120, Germany

4. Centre for Advanced Materials, Heidelberg University, Im Neuenheimer Feld 225, Heidelberg 69120, Germany

5. Department of Chemistry, University of Konstanz, Universitätsstraße 10, Konstanz 78457, Germany

Abstract

A combinatorial approach toward novel functional WW domains based on coiled-coil-mediated reconstitution of split WW domains is presented. As such, an ATP-binding WW domain was found from a 4-by-6 library of N- and C-terminal WW domain fragments.

Funder

Carl-Zeiss-Stiftung

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01078J

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