A sustainable and scalable multicomponent continuous flow process to access fused imidazoheterocycle pharmacophores-Reference-Cited by-同舟云学术

A sustainable and scalable multicomponent continuous flow process to access fused imidazoheterocycle pharmacophores

Published:2021 Issue:1 Volume:23 Page:280-287
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Baker Blake J. M.¹²³⁴⁵,Kerr William J.⁴⁵⁶³^ORCID,Lindsay David M.⁴⁵⁶³^ORCID,Patel Vipulkumar K.¹²³,Poole Darren L.¹²³^ORCID

Affiliation:

1. GlaxoSmithKline Medicines Research Centre

2. Stevenage

3. UK

4. Department of Pure and Applied Chemistry

5. University of Strathclyde

6. Glasgow

Abstract

A sustainable flow process has been established for the application of the Gröebke–Blackburn–Bienaymé reaction for access to high-value fused heteroaromatics.

Funder

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/GC/D0GC03675G

Reference49 articles.

1. Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

2. P. T. Anastas and J. C.Warner , Green Chemistry: Theory and Practice , Oxford University Press , New York , 1998

3. Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

4. N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase

5. Biased Multicomponent Reactions to Develop Novel Bromodomain Inhibitors

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