Discovery of potential hypoglycemic metabolites in Cassiae Semen by coupling UHPLC-QTOF-MS/MS combined plant metabolomics and spectrum-effect relationship analyses

Author:

Yang Fei1,Zou Yanfang1,Li Chenyue1,Li Jiaxu1,Zang Yaping1,Peng Xin2,Wang Juan3,Liu E-Hu4,Tong Shengqiang1ORCID,Chu Chu1ORCID

Affiliation:

1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, P. R. China

2. Ningbo Research Institute of Traditional Chinese Medicine, Ningbo, 315100, P. R. China

3. Zhejiang Pharmaceutical College, Ningbo, 315100, P. R. China

4. State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, P. R. China

Abstract

A comprehensive strategy by combining plant metabolomics and spectrum-effect relationship is developed for the rapid and efficient discrimination of raw and fried Cassiae Semen and discovery of potential hypoglycemic metabolites for quality control.

Funder

National Natural Science Foundation of China

Department of Education of Zhejiang Province

State Key Laboratory of Natural Medicines

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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