The differences of the impact of a lipid and protein corona on the colloidal stability, toxicity, and degradation behavior of iron oxide nanoparticles-Reference-Cited by-同舟云学术

The differences of the impact of a lipid and protein corona on the colloidal stability, toxicity, and degradation behavior of iron oxide nanoparticles

Published:2021 Issue:20 Volume:13 Page:9415-9435
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Rabel Martin¹²³⁴,Warncke Paul¹²³⁴,Thürmer Maria⁵²³⁴,Grüttner Cordula⁶⁷⁴,Bergemann Christian⁸⁹⁴,Kurland Heinz-Dieter¹⁰²³⁴,Müller Frank A.¹⁰²³⁴,Koeberle Andreas⁵²³⁴¹¹^ORCID,Fischer Dagmar¹²¹³¹⁴⁴^ORCID

Affiliation:

1. Pharmaceutical Technology and Biopharmacy

2. Friedrich-Schiller-University Jena

3. 07743 Jena

4. Germany

5. Department of Pharmaceutical and Medical Chemistry

6. micromod Partikeltechnologie GmbH

7. 18119 Rostock

8. chemicell GmbH

9. 12103 Berlin

10. Otto Schott Institute of Materials Research (OSIM)

11. Michael Popp Institute and Center for Molecular Biosciences Innsbruck (CMBI)

12. Department of Chemistry and Pharmacy

13. Friedrich-Alexander-University Erlangen-Nuremberg

14. 91058 Erlangen

Abstract

It was shown that proteins and lipids adsorb to the surface of IONP improving their colloidal stability and biocompatibility profile in vitro and in vivo. The degradation rate was reduced and correlated with the lipid but not the protein adsorption.

Funder

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR09053K

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