The membrane-targeting mechanism of host defense peptides inspiring the design of polypeptide-conjugated gold nanoparticles exhibiting effective antibacterial activity against methicillin-resistant Staphylococcus aureus

Author:

Zhang Weiwei1234ORCID,Wu Yueming1234ORCID,Liu Longqiang56723,Xiao Ximian56723,Cong Zihao56723ORCID,Shao Ning56723ORCID,Qiao Zhongqian56723ORCID,Chen Kang56723,Liu Shiqi56723,Zhang Haodong56723ORCID,Ji Zhemin56723,Shao Xiaoyan894,Dai Yidong894,He Hongyan56723,Xia Jiang1011124ORCID,Fei Jian1314154,Liu Runhui12345ORCID

Affiliation:

1. State Key Laboratory of Bioreactor Engineering

2. East China University of Science and Technology

3. Shanghai 200237

4. China

5. Key Laboratory for Ultrafine Materials of Ministry of Education

6. Frontiers Science Center for Materiobiology and Dynamic Chemistry

7. Research Center for Biomedical Materials of Ministry of Education

8. Shanghai Ruijin Rehabilitation Hospital

9. Shanghai 200023

10. Department of Chemistry

11. The Chinese University of Hong Kong

12. Shatin

13. Department of General Surgery

14. Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

15. Shanghai 200025

Abstract

The membrane-targeting mechanism of host defense peptides inspiring the design of polypeptide-conjugated gold nanoparticles exhibiting effective antibacterial activity against methicillin-resistant Staphylococcus aureus.

Funder

National Natural Science Foundation of China

Program of Shanghai Academic Research Leader

Fundamental Research Funds for the Central Universities

State Key Laboratory of Bioreactor Engineering

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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