Facile Construction of Antimicrobial Surface via One‐Step Co‐Deposition of Peptide Polymer and Dopamine

Abstract

AbstractThe infections associated with implantable medical devices can greatly affect the therapeutic effect and impose a heavy financial burden. Therefore, it is of great significance to develop antimicrobial biomaterials for the prevention and mitigation of healthcare‐associated infections. Here, a facile construction of antimicrobial surface via one‐step co‐deposition of peptide polymer and dopamine is reported. The co‐deposition of antimicrobial peptide polymer DLL60BLG40 with dopamine (DA) on the surface of thermoplastic polyurethane (TPU) provides peptide polymer‐modified TPU surface (TPU‐DLL60BLG40). The antimicrobial test shows that the TPU‐DLL60BLG40 surfaces of the sheet and the catheter both exhibit potent killing of 99.9% of methicillin‐resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). In addition, the TPU‐DLL60BLG40 surface also exhibits excellent biocompatibility. This one‐step antimicrobial modification method is fast and efficient, implies promising application in surface antimicrobial modification of implantable biomaterials and medical devices.