Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring-Reference-Cited by-同舟云学术

Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring

Published:2017 Issue:37 Volume:15 Page:7770-7782
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Rashad Adel A.¹²³⁴^ORCID,Acharya Kriti¹²³⁴^ORCID,Haftl Ann¹²³⁴^ORCID,Aneja Rachna¹²³⁴,Dick Alexej¹²³⁴,Holmes Andrew P.¹²³⁴^ORCID,Chaiken Irwin¹²³⁴

Affiliation:

1. Department of Biochemistry & Molecular Biology

2. Drexel University College of Medicine

3. Philadelphia

4. USA

Abstract

HIV-1 entry inhibition remains an urgent need for AIDS drug discovery. cPTs belong to a class of entry inhibitors that block Env binding to cellular receptors and trigger Env-gp120 shedding.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01448A

Reference46 articles.

1. Native-like Env trimers as a platform for HIV-1 vaccine design

2. HIV's Achilles' Heel

3. Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals

4. HIV-1 Antiretroviral Drug Therapy

5. Antiretroviral therapy and management of HIV infection

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