Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring

Author:

Rashad Adel A.1234ORCID,Acharya Kriti1234ORCID,Haftl Ann1234ORCID,Aneja Rachna1234,Dick Alexej1234,Holmes Andrew P.1234ORCID,Chaiken Irwin1234

Affiliation:

1. Department of Biochemistry & Molecular Biology

2. Drexel University College of Medicine

3. Philadelphia

4. USA

Abstract

HIV-1 entry inhibition remains an urgent need for AIDS drug discovery. cPTs belong to a class of entry inhibitors that block Env binding to cellular receptors and trigger Env-gp120 shedding.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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