Synthesis of fused 1,2-naphthoquinones with cytotoxic activity using a one-pot three-step reaction
Author:
Affiliation:
1. Department of Organic Chemistry
2. Faculty of Science
3. Charles University
4. 128 00 Praha 2
5. Czech Republic
6. Department of Inorganic Chemistry
Abstract
Biologically active 1,2-naphthoquinones, structurally related to natural products, were synthesised using a palladium-catalysed tandem reaction to form naphthalenes, followed by oxidation with trivalent iodine reagents.
Funder
Grantová Agentura České Republiky
Univerzita Karlova v Praze
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB00205H
Reference64 articles.
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2. Bioinspired Synthesis of Pygmaeocins and Related Rearranged Abietane Diterpenes: Synthesis of Viridoquinone
3. Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells
4. Synthesis, Characterization, and Antileukemic Properties of Naphthoquinone Derivatives of Lawsone
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