Synthesis of fused 1,2-naphthoquinones with cytotoxic activity using a one-pot three-step reaction

Author:

Nechaev Anton A.12345,Jagtap Pratap R.12345ORCID,Bažíková Ema12345,Neumannová Johana12345,Císařová Ivana62345,Matoušová Eliška12345ORCID

Affiliation:

1. Department of Organic Chemistry

2. Faculty of Science

3. Charles University

4. 128 00 Praha 2

5. Czech Republic

6. Department of Inorganic Chemistry

Abstract

Biologically active 1,2-naphthoquinones, structurally related to natural products, were synthesised using a palladium-catalysed tandem reaction to form naphthalenes, followed by oxidation with trivalent iodine reagents.

Funder

Grantová Agentura České Republiky

Univerzita Karlova v Praze

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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