Aminated β-cyclodextrin-grafted Fe3O4-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation

Author:

Fang Wei1234,Dai Ya Ji12345,Wang Ting1234,Gao Hai Tao1234,Huang Peng1234,Yu Juan1234,Huang He Ping1234,Wang Dian Lei12346ORCID,Zong Wei Lu1234

Affiliation:

1. The College of Pharmacy

2. Anhui University of Chinese Medicine

3. Hefei

4. China

5. Anhui Second People's Hospital

6. Anhui Province Key Laboratory of Chinese Medicinal Formula

Abstract

Based on aminated β-cyclodextrin (6-NH2-β-CD)-grafted Fe3O4 and gambogic acid clathrate complexes, a nanoparticle delivery system was developed with the aim of achieving low irritation, strong targeting and high bioavailability of a gambogic acid magnetic nanopreparation.

Funder

National Natural Science Foundation of China

Anhui Department of Education

Anhui Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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