Improved druggability of gambogic acid using core–shell nanoparticles-Reference-Cited by-同舟云学术

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Improved druggability of gambogic acid using core–shell nanoparticles

Published:2019 Issue:3 Volume:7 Page:1028-1042
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Liu Fulei¹²³⁴⁵^ORCID,Huang Xiaoxian¹²³⁴,Han Lingfei⁶²³⁴⁷^ORCID,Sang Mangmang⁶²³⁴⁷,Hu Lejian¹²³⁴,Liu Bowen¹²³⁴,Duan Bingjing¹²³⁴,Jiang Pan¹²³⁴,Wang Xin⁶²³⁴⁷,Qiao Zhou⁶²³⁴⁷,Ma Congyu⁶²³⁴⁷,Liu Wenyuan⁶²³⁴⁷,Liu Jun⁵⁸⁹⁴,Feng Feng¹²³⁴¹⁰,Qu Wei¹²³⁴¹⁰

Affiliation:

1. Department of Natural Medicinal Chemistry

2. China Pharmaceutical University

3. Nanjing 210009

4. China

5. The Joint Laboratory of Chinese Pharmaceutical University and Taian City Central Hospital

6. Department of Pharmaceutical Analysis

7. Key Laboratory of Drug Quality Control and Pharmacovigilance

8. Taian City Central Hospital

9. Taian

10. Key Laboratory of Biomedical Functional Materials

Abstract

A core-shell hybrid nanoparticle has been developed to improve the druggability of Gambogic acid (GA), a natural antitumor drug candidate.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/BM/C8BM01154K

Reference57 articles.

1. Studies on the toxicity of gambogic acid in rats

2. The role of p53 in cancer drug resistance and targeted chemotherapy

3. Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells

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