Transient binding promotes molecule penetration into mucin hydrogels by enhancing molecular partitioning
Author:
Affiliation:
1. Department of Mechanical Engineering and Munich School of Bioengineering
2. Technical University of Munich
3. Garching
4. Germany
5. Physics Department
6. 85748 Garching
Abstract
Charged, mucoadhesive molecules can penetrate mucin-based hydrogels such as native mucus with similar efficiency as inert, non-mucoadhesive molecules.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science,Biomedical Engineering
Link
http://pubs.rsc.org/en/content/articlepdf/2018/BM/C8BM00664D
Reference69 articles.
1. Biological hydrogels as selective diffusion barriers
2. Mucin dynamics and enteric pathogens
3. The particle in the spider's web: transport through biological hydrogels
4. Distribution of Sialic Acids on Mucins and Gels: A Defense Mechanism
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