Discovery of a selective TC-PTP degrader for cancer immunotherapy-Reference-Cited by-同舟云学术

Discovery of a selective TC-PTP degrader for cancer immunotherapy

Published:2023 Issue:44 Volume:14 Page:12606-12614
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Miao Jinmin¹,Dong Jiajun¹,Miao Yiming¹,Bai Yunpeng¹^ORCID,Qu Zihan²,Jassim Brenson A.¹,Huang Bo²,Nguyen Quyen²^ORCID,Ma Yuan¹,Murray Allison A.¹^ORCID,Li Jinyue¹,Low Philip S.²³⁴,Zhang Zhong-Yin¹²³⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA

2. Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA

3. Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA

4. Institute for Drug Discovery, Purdue University, West Lafayette, IN 47907, USA

Abstract

We report the first, potent and selective PROTAC degrader for TC-PTP. The degrader enhances TC-PTP substrates’ phosphorylation levels, promotes antigen presentation in tumor, and enhances T-cell activation and CAR-T cell efficiency.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC04541B

Reference44 articles.

1. Trends in kinase drug discovery: targets, indications and inhibitor design

2. Functional interrogation and therapeutic targeting of protein tyrosine phosphatases

3. Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase.

4. PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia

5. The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3

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