Affiliation:
1. Department of Chemistry Purdue University West Lafayette Indiana USA
2. Borch Department of Medicinal Chemistry and Molecular Pharmacology Purdue University West Lafayette Indiana USA
3. Institute for Cancer Research Purdue University West Lafayette Indiana USA
4. Institute for Drug Discovery Purdue University West Lafayette Indiana USA
Abstract
AbstractContemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear. Protein tyrosine phosphatases (PTPs) wield a pivotal regulatory influence over an array of essential cellular processes. Substantial research has underscored the potential in targeting PTPs to modulate the immune responses and/or regulate antigen presentation, thereby presenting a novel paradigm for cancer immunotherapy. In this review, we focus on recent advances in genetic and biological validation of several PTPs as emerging targets for immunotherapy. We also highlight recent development of small molecule inhibitors and degraders targeting these PTPs as novel cancer immunotherapeutic agents.
Funder
National Institutes of Health