The one pot asymmetric synthesis of 3,3′-pyrrolidonyl spiroxindoles via a regio- and stereoselective domino reaction-Reference-Cited by-同舟云学术

The one pot asymmetric synthesis of 3,3′-pyrrolidonyl spiroxindoles via a regio- and stereoselective domino reaction

Published:2019 Issue:35 Volume:17 Page:8140-8148
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hajra Saumen¹²³⁴^ORCID,Bhosale Suhas Shivajirao¹²³⁴^ORCID,Hazra Atanu¹²³⁴^ORCID,Kanaujia Nikhil¹²³⁴

Affiliation:

1. Centre of Biomedical Research

2. Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus

3. Lucknow 226014

4. India

Abstract

The asymmetric synthesis of 4-aryl-3,3′-spiropyrrolidonyl oxindoles with excellent stereoselectivity (dr >99 : 1 and an ee up to >99%) was achieved via a domino reaction.

Funder

Ministry of Earth Sciences

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB01570A

Reference42 articles.

1. Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

2. Pyrrolidinyl-Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

3. Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

4. Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids

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