Mechanistic insights into the mitigation of Aβ aggregation and protofibril destabilization by a <scp>d</scp>-enantiomeric decapeptide rk10-Reference-Cited by-同舟云学术

Mechanistic insights into the mitigation of Aβ aggregation and protofibril destabilization by a d-enantiomeric decapeptide rk10

Published:2022 Issue:36 Volume:24 Page:21975-21994
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Singh Kamaljot¹^ORCID,Kaur Anupamjeet¹^ORCID,Goyal Deepti²^ORCID,Goyal Bhupesh³^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Basic and Applied Sciences, Sri Guru Granth Sahib World University, Fatehgarh Sahib-140406, Punjab, India

2. Department of Chemistry, DAV College, Sector 10, Chandigarh-160011, India

3. School of Chemistry & Biochemistry, Thapar Institute of Engineering & Technology, Patiala-147004, Punjab, India

Abstract

MD simulations highlighted that rk10 induces a significant increase in helical and a complete reduction of β–sheet content in Aβ42 monomer. Remarkably, rk10 destabilized Aβ42 protofibril by lowering the binding affinity between protofibril chains.

Funder

Science and Engineering Research Board

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CP/D2CP02601E

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