The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters-Reference-Cited by-同舟云学术

The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters

Published:2021 Issue:16 Volume:57 Page:2069-2072
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Xie Shaolei¹²³⁴⁵,He Zhi-Juan¹²³⁴,Zhang Ling-Hui¹²³⁴,Huang Bo-Lun¹²³⁴,Chen Xiao-Wei¹²³⁴,Zhan Zong-Song¹²³⁴,Zhang Fu-Min¹²³⁴⁶^ORCID

Affiliation:

1. State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering

2. Lanzhou University

3. Lanzhou 730000

4. China

5. Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources, Qinghai

6. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development

Abstract

We developed, for the first time, the cinchona-alkaloid-catalyzed enantiodivergent α-fluorination of β-keto diarylphosphine oxides, which resulted in two enantiomers bearing fluorine-containing quaternary stereocenters.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC07770D

Reference79 articles.

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