Heparin assisted assembly of somatostatin amyloid nanofibrils results in disordered precipitates by hindrance of protofilaments interactions-Reference-Cited by-同舟云学术

Heparin assisted assembly of somatostatin amyloid nanofibrils results in disordered precipitates by hindrance of protofilaments interactions

Published:2018 Issue:38 Volume:10 Page:18195-18204
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Dharmadana Durga¹²³⁴⁵^ORCID,Reynolds Nicholas P.⁶⁷³⁴^ORCID,Dekiwadia Chaitali⁸²³⁴,Conn Charlotte E.⁵²³⁴^ORCID,Valéry Céline¹²³⁴^ORCID

Affiliation:

1. School of Health and Biomedical Sciences

2. RMIT University

3. Melbourne

4. Australia

5. School of Science

6. ARC Training Center for Biodevices

7. Swinburne University

8. RMIT Microscopy and Microanalysis Facility

Abstract

We show that the self-assembly of the functional amyloid forming neuropeptide somatostatin-14 is dramatically altered by the presence of GAGs such as heparin and chondroitin sulphate. This work highlights the dangers of using such polymeric sugars as supposedly “inert” amyloid aggregation promotors.

Funder

Australian Research Council

Diabetes Australia Research Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2018/NR/C8NR02159G

Reference36 articles.

1. Spontaneous fibrillation of the native neuropeptide hormone Somatostatin-14

2. Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules