Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules-Reference-Cited by-同舟云学术

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

Published:2009-07-17 Issue:5938 Volume:325 Page:328-332
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Maji Samir K.¹,Perrin Marilyn H.²,Sawaya Michael R.³,Jessberger Sebastian⁴,Vadodaria Krishna⁴,Rissman Robert A.⁵,Singru Praful S.⁶,Nilsson K. Peter R.⁷,Simon Rozalyn⁷,Schubert David⁸,Eisenberg David³,Rivier Jean²,Sawchenko Paul²,Vale Wylie²,Riek Roland¹⁹

Affiliation:

1. Laboratory of Physical Chemistry, Eidgenössische Technische Hochschule (ETH) Zürich, Wolfgang-Paulistrasse 10, CH-8093 Zürich, Switzerland.

2. Clayton Foundation Laboratories for Peptide Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

3. Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Box 951570, University of California, Los Angeles, CA 90095, USA.

4. Institute of Cell Biology, Department of Biology, ETH Zürich, 8093 Zürich, Switzerland.

5. Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093, USA.

6. Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA 02111, USA.

7. Department of Chemistry, IFM, Linköping University, SE-581 83 Linköping, Sweden.

8. Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

9. Structural Biology, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Plethora of Secretory Amyloids Protein aggregation and the formation of amyloids are associated with several dozen pathological conditions in humans, including Alzheimer's disease, Parkinson's disease, and type II diabetes. In addition, a few functional amyloid systems are known: the prions of fungi, the bacterial protein curli, the protein of chorion of the eggshell of silkworm, and the amyloid protein Pmel-17 involved in mammalian skin pigmentation. Now Maji et al. (p. 328 , published online 18 June) propose that endocrine hormone peptides and proteins are stored in an amyloid-like state in secretory granules. Thus, the amyloid fold may represent a fundamental, ancient, and evolutionarily conserved protein structural motif that is capable of performing a wide variety of functions contributing to normal cell and tissue physiology.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Pathways of Protein Secretion in Eukaryotes

2. From organelle to organelle

3. Sorting and storage during secretory granule biogenesis: looking backward and looking forward

4. Concentrating hormones into secretory granules: layers of control

5. Lumenal protein multimerization in the distal secretory pathway/secretory granules

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