Bioimaging of glutathione variation for early diagnosis of hepatocellular carcinoma using a liver-targeting ratiometric near-infrared fluorescent probe

Author:

Han Xiaoyue1,Xing Yanlong23,Song Xinyu4,Dou Kun23,Yu Fabiao23ORCID,Chen Lingxin1ORCID

Affiliation:

1. CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China

2. Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou 571199, China

3. Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou 571199, China

4. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medicine University, Guangzhou 510120, China

Abstract

We report a ratiometric near-infrared fluorescent probeCyO-Disufor the selective detection of GSH variation in living cells and mice models of Hepatocellular carcinoma.CyO-Disucan serve as a promising chemical tool for the early diagnosis and precise treatment of cancer.

Funder

National Natural Science Foundation of China

Hainan Provincial Department of Science and Technology

Hainan Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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