NKT cell-dependent glycolipid–peptide vaccines with potent anti-tumour activity

Author:

Anderson Regan J.1234ORCID,Compton Benjamin J.1234ORCID,Tang Ching-wen564,Authier-Hall Astrid564,Hayman Colin M.1234,Swinerd Gene W.56472,Kowalczyk Renata7894,Harris Paul7894,Brimble Margaret A.789410,Larsen David S.1112134,Gasser Olivier564,Weinkove Robert5641415ORCID,Hermans Ian F.564108,Painter Gavin F.1234ORCID

Affiliation:

1. The Ferrier Research Institute

2. Victoria University of Wellington

3. Lower Hutt 5046

4. New Zealand

5. Malaghan Institute of Medical Research

6. Wellington 6242

7. School of Biological Sciences

8. The University of Auckland

9. Auckland Central

10. Maurice Wilkins Centre for Molecular Biodiscovery

11. Department of Chemistry

12. University of Otago

13. Dunedin 9054

14. Department of Pathology & Molecular Medicine

15. University of Otago Wellington

Abstract

Glycolipid–peptide conjugates designed to release vaccine components within target cells ensuring potent CD1d dependent T cell responses.

Funder

Genesis Oncology Trust

Ministry of Science and Innovation, New Zealand

Health Research Council of New Zealand

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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