Targeting abasic site-containing DNA with annelated quinolizinium derivatives: the influence of size, shape and substituents-Reference-Cited by-同舟云学术

Targeting abasic site-containing DNA with annelated quinolizinium derivatives: the influence of size, shape and substituents

Published:2014 Issue:11 Volume:12 Page:1725-1734
ISSN:1477-0520
Container-title:Org. Biomol. Chem.
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Benner Katja¹²³,Ihmels Heiko¹²³,Kölsch Sarah¹²³,Pithan Phil M.¹²³

Affiliation:

1. University of Siegen

2. Organic Chemistry II

3. Siegen, Germany

Abstract

A comparative analysis showed that the type and degree of annelation as well as methyl or chloro-substitution are relevant structural features that determine the interactions of quinolizinium derivatives with abasic site-containing DNA.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/OB/C3OB42140F

Reference87 articles.

1. Investigating the Biochemical Impact of DNA Damage with Structure-Based Probes: Abasic Sites, Photodimers, Alkylation Adducts, and Oxidative Lesions

2. An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

3. Instability and decay of the primary structure of DNA

4. The major human abasic endonuclease: formation, consequences and repair of abasic lesions in DNA

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