Affiliation:
1. Department of Chemistry-Biology University of Siegen Adolf-Reichwein-Str. 2 57068 Siegen Germany
2. A. N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences Vavilova str. 28 119991 Moscow Russia
Abstract
AbstractThe photocyclization reaction of sterically demanding styrylpyridine derivatives was investigated and shown to depend on the type of substituent. With this method, a 2,2‐diphenyl‐1,3‐benzodioxolo‐annelated benzo[c]quinolizinium was synthesized, and its association with regular and abasic site‐containing DNA (AP‐DNA) was investigated by absorption, fluorescence, circular and linear dichroism spectroscopy. Specifically, this ligand binds preferentially to AP‐DNA relative to regular duplex DNA, and the AP‐DNA/ligand complex is formed in situ upon irradiation of the styrylpyridine substrate in the presence of the DNA.
Funder
Deutsche Forschungsgemeinschaft
Universität Siegen
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Analytical Chemistry
Cited by
1 articles.
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