Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine-Reference-Cited by-同舟云学术

Making biological membrane resistant to the toxicity of misfolded protein oligomers: a lesson from trodusquemine

Published:2020 Issue:44 Volume:12 Page:22596-22614
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Errico Silvia¹²³⁴⁵,Lucchesi Giacomo⁶³⁷⁵,Odino Davide⁸⁹¹⁰⁵,Muscat Stefano¹¹¹²¹³¹⁴¹⁵^ORCID,Capitini Claudia¹⁶⁷⁵¹⁷³,Bugelli Chiara¹²³⁴⁵,Canale Claudio⁸⁹¹⁰⁵,Ferrando Riccardo⁸⁹¹⁰⁵^ORCID,Grasso Gianvito¹¹¹²¹³¹⁴¹⁵,Barbut Denise¹⁸¹⁹²⁰,Calamai Martino¹⁶⁷⁵²¹²²,Danani Andrea¹¹¹²¹³¹⁴¹⁵^ORCID,Zasloff Michael¹⁸¹⁹²⁰²³²⁴,Relini Annalisa⁸⁹¹⁰⁵^ORCID,Caminati Gabriella⁶³⁷⁵^ORCID,Vendruscolo Michele²⁵²⁶²⁷²⁸²⁹^ORCID,Chiti Fabrizio¹²³⁴⁵^ORCID

Affiliation:

1. Department of Experimental and Clinical Biomedical Sciences

2. Section of Biochemistry

3. University of Florence

4. Florence

5. Italy

6. Department of Chemistry “Ugo Schiff” and CSGI

7. Sesto Fiorentino

8. Department of Physics

9. University of Genoa

10. Genoa

11. Dalle Molle Institute for Artificial Intelligence (IDSIA)

12. University of Applied Sciences and Arts of Southern Switzerland (SUPSI)

13. University of Italian Switzerland (USI)

14. Lugano

15. Switzerland

16. European Laboratory for Non-linear Spectroscopy (LENS)

17. Department of Physics and Astronomy

18. Enterin Inc.

19. Philadelphia

20. USA

21. National Institute of Optics

22. National Research Council of Italy (CNR)

23. MedStar-Georgetown Transplant Institute

24. Georgetown University School of Medicine

25. Centre for Misfolding Diseases

26. Department of Chemistry

27. University of Cambridge

28. Cambridge

29. UK

Abstract

Trodusquemine penetrates biological membranes and modulates their physicochemical properties, increasing their resistance to misfolded protein oligomers associated with neurodegenerative diseases.

Funder

Università degli Studi di Firenze

H2020 European Research Council

Regione Toscana

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NR/D0NR05285J

Reference67 articles.

1. Spreading of pathology in neurodegenerative diseases: a focus on human studies