Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Author:

Perni Michele12ORCID,Flagmeier Patrick12ORCID,Limbocker Ryan12,Cascella Roberta3,Aprile Francesco A.12ORCID,Galvagnion Céline14ORCID,Heller Gabriella T.12ORCID,Meisl Georg12ORCID,Chen Serene W.12,Kumita Janet R.12ORCID,Challa Pavan K.12ORCID,Kirkegaard Julius B.5,Cohen Samuel I. A.12,Mannini Benedetta12,Barbut Denise6,Nollen Ellen A. A.7,Cecchi Cristina3,Cremades Nunilo8ORCID,Knowles Tuomas P. J.129ORCID,Chiti Fabrizio3ORCID,Zasloff Michael610,Vendruscolo Michele12ORCID,Dobson Christopher M.12ORCID

Affiliation:

1. Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom

2. Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom

3. Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, Italy

4. German Centre for Neurodegenerative Diseases, DZNE, Sigmund-Freud-Strasse. 27, 53127, Bonn, Germany

5. Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge CB3 0WA, United Kingdom

6. Enterin Inc., 3624 Market Street, Philadelphia, Pennsylvania 19104, United States

7. University Medical Centre Groningen, European Research Institute for the Biology of Aging, University of Groningen, Groningen 9713 AV, The Netherlands

8. Institute for Biocomputation and Physics of Complex Systems (BIFI)-Joint Unit BIFI-IQFR (CSIC), University of Zaragoza, 50018 Zaragoza, Spain

9. Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, United Kingdom

10. MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC 20010, United States

Funder

Alzheimer's Society

Boehringer Ingelheim Fonds

Ministerio de Economía y Competitividad

Gates Cambridge Trust

Studienstiftung des Deutschen Volkes

H2020 Marie Sklodowska-Curie Actions

Wellcome Trust

Frances and Augustus Newman Foundation

Biotechnology and Biological Sciences Research Council

Sidney Sussex College, University of Cambridge

Centre for Misfolding Diseases, University of Cambridge

Fondo per lo Sviluppo e la Coesione

Regione Toscana

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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