Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins-Reference-Cited by-同舟云学术

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

Published:2014-05-30 Issue:6187 Volume:344 Page:1023-1028
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wilhelm Benjamin G.¹²,Mandad Sunit³,Truckenbrodt Sven¹⁴,Kröhnert Katharina¹,Schäfer Christina¹,Rammner Burkhard¹,Koo Seong Joo⁵,Claßen Gala A.⁵,Krauss Michael⁵,Haucke Volker⁵,Urlaub Henning³⁶,Rizzoli Silvio O.¹

Affiliation:

1. Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, European Neuroscience Institute, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain, Göttingen, Germany.

2. International Max Planck Research School Neurosciences, 37077 Göttingen, Germany.

3. Bioanalytical Mass Spectrometry Group, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany.

4. International Max Planck Research School Molecular Biology, 37077 Göttingen, Germany.

5. Leibniz Institut für Molekulare Pharmakologie, Department of Molecular Pharmacology and Cell Biology, Robert-Rössle-Strasse 10, 13125 Berlin, Germany.

6. Bioanalytics, Department of Clinical Chemistry, University Medical Center Göttingen, 37075 Göttingen, Germany.

Abstract

High-definition view of the synapse Individual neurons communicate with one another via their synapses, so to understand the nervous system, we need to understand in detail how the synapses are organized. Wilhelm et al. present a quantitative molecular-scale image of the “average” synapse populated with realistic renditions of each of the protein components that contribute to the inner workings of neurons. Science , this issue p. 1023

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference46 articles.

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