On the relaxation dynamics in active pharmaceutical ingredients: solid-state 1H NMR, quasi-elastic neutron scattering and periodic DFT study of acebutolol hydrochloride-Reference-Cited by-同舟云学术

On the relaxation dynamics in active pharmaceutical ingredients: solid-state 1H NMR, quasi-elastic neutron scattering and periodic DFT study of acebutolol hydrochloride

Published:2015 Issue:71 Volume:5 Page:57502-57514
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Pajzderska A.¹²³⁴⁵,Drużbicki K.¹²³⁴⁵,Kiwilsza A.¹²³⁴⁵,Gonzalez M. A.⁶⁷⁸,Jarek M.⁹¹⁰⁴⁵,Mielcarek J.¹¹¹²¹³⁵,Wąsicki J.¹²³⁴⁵

Affiliation:

1. Department of Radiospectroscopy

2. Faculty of Physics

3. Adam Mickiewicz University

4. Poznan

5. Poland

6. Institute Laue Langevin

7. 38042 Grenoble Cedex 9

8. France

9. The NanoBioMedical Center

10. A. Mickiewicz University

11. Department of Inorganic and Analytical Chemistry

12. Poznan University of Medical Science

13. 60-780 Poznan

Abstract

Molecular dynamics of acebutolol hydrochloride was thoroughly explored by combining QENS and NMR experiments with solid-state DFT calculations.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA08937A

Reference53 articles.

1. W. C. McCrone , in Physics and Chemistry of the Organic Solid State, ed. D. Fox, M. M. Labes and A. Weissberger, Interscience Publishers, London, 1965, vol. 2, pp. 725–767

2. Pharmacokinetics of Acebutolol Enantiomers in Humans

3. Polymorphism of Acebutolol Hydrochloride

4. Chlorhydrate d'acébutolol [(hydroxy-2 isopropylamino-3 propoxy)-2 butyrylamino-5 acétophénone chlorhydraté]

5. 35Cl solid-state NMR of HCl salts of active pharmaceutical ingredients: structural prediction, spectral fingerprinting and polymorph recognition

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