Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper–tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer-Reference-Cited by-同舟云学术

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Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper–tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer

Published:2020 Issue:9 Volume:8 Page:2420-2433
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Silva Vera L.¹²³⁴⁵,Kaassis Abdessamad¹²³⁴⁵,Dehsorkhi Ashkan¹²³⁴⁵,Koffi Cédrik-Roland¹⁶⁷⁵,Severic Maja¹⁶⁷⁵,Abdelhamid Moustafa¹²³⁴⁵,Nyimanu Duuamene¹²³⁴⁵,Morris Christopher J.¹²³⁴⁵,Al-Jamal Wafa’ T.¹²³⁴⁵^ORCID

Affiliation:

1. School of Pharmacy

2. University of East Anglia

3. Norwich Research Park

4. Norwich

5. UK

6. Queen's University Belfast

7. Belfast

Abstract

Cu(TPZ)₂ complex as a promising hypoxia selective cytotoxin in prostate cancer.

Funder

Prostate Cancer UK

Engineering and Physical Sciences Research Council

University of East Anglia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/BM/C9BM01905G

Reference50 articles.

1. The role of hypoxia-activated prodrugs in cancer therapy

2. Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

3. SR 4233 (Tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours

4. Tirapazamine: From Bench to Clinical Trials

5. Tirapazamine: a novel agent targeting hypoxic tumor cells

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