Tirapazamine: a novel agent targeting hypoxic tumor cells
Author:
Publisher
Informa Healthcare
Subject
Pharmacology (medical),Pharmacology,General Medicine
Link
http://www.tandfonline.com/doi/pdf/10.1517/13543780802567250
Reference44 articles.
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3. SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
4. Metabolism of tirapazamine by multiple reductases in the nucleus11Abbreviations: TPZ, tirapazamine; P450 reductase, NADPH:cytochrome P450 reductase; PMSF, phenylmethylsulfonyl fluoride; DTT, dithiothreitol; DHR123, dihydrorhodamine 123; DAPI, 4′,6-diamidino-2-phenylindole, dihydrochloride; SN, supernatant from nuclei; LS, low salt; HS, high salt; and NM, nuclear matrix.
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