Thermo and pH dual-controlled charge reversal amphiphilic graft copolymer micelles for overcoming drug resistance in cancer cells

Author:

Zhang Haitao12345,Fan Xiaodong12345,Li Fei678,Suo Rongtian12345,Li Hui12345,Yang Zhen12345,Zhang Wanbin12345,Bai Yang9510,Tian Wei12345

Affiliation:

1. The Key Laboratory of Space Applied Physics and Chemistry

2. Ministry of Education and Shaanxi Key Laboratory of Macromolecular Science and Technology

3. School of Science

4. Northwestern Polytechnical University

5. Xi'an

6. Department of Pharmacy

7. Ji'nan

8. China

9. Xi'an Modern Chemistry Research Institute

10. P. R. China

Abstract

A novel thermo and pH dual-controlled charge reversal PSMA89-g-P(DMA16-co-SD56) graft copolymer micelle was developed with effectively enhanced cellular uptake for overcoming multi-drug resistance in cancer cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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